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The median codeine and metabolite plasma concentration versus time profile for codeine before oral and i.v. metformin and codeine together with oral and i.v. metformin in 16 healthy volunteers. Data is presented with 25th–75th interquartile range (IQR) error bars. Brown with stars = morphine; blue with circles = M3G; purple with triangles = M6G; green with squares = codeine, and pink with diamonds = C6G
