Table 5. Univariate and multivariate analysis of clinicopathological factors associated with overall survival post-hepatectomy.
| Variables | 5-year OS rate (%) | Univariate P-value | Multivariate analysis | |
|---|---|---|---|---|
| HR (95% CI) | P-value | |||
| < Metastatic tumor characteristics > | ||||
| Age (<65 years / ≥65 years) | 64.2 / 59.8 | 0.968 | ||
| Sex (men/women) | 64.2 / 56.3 | 0.698 | ||
| Tumor maximum size (<5 cm / ≥5 cm) | 65.3 / 50.0 | 0.089 | ||
| Tumor number (<4 cm / ≥4 cm) | 66.4 / 52.8 | 0.269 | ||
| H-stage (H1/H2, 3) | 72.7 / 44.4 | 0.020 | 0.36 (0.11–1.89) | 0.291 |
| Grade (A/B,C) | 77.5 / 46.2 | 0.012 | 0.34 (0.08–1.39) | 0.148 |
| Metastasis period (synch/meta) | 52.3 / 74.5 | 0.124 | ||
| Pre-operative chemotherapy (-: +) | 60.2 / 100 | 0.307 | ||
| Post-operative chemotherapy (-: +) | 71.1 / 59.0 | 0.586 | ||
| Nomogram preoperative score (<11 / ≥11) | 81.8 / 49.3 | 0.020 | 0.50 (0.12–1.96) | 0.292 |
| PD-1 (-: +) | 53.2 / 87.7 | 0.023 | 0.19 (0.03–1.10) | 0.032 |
| PD-L1 (-: +) | 42.3 / 82.3 | 0.007 | 0.64 (0.23–1.77) | 0.382 |
| IDO (-: +) | 43.5 / 80.7 | 0.007 | 0.37 (0.13–1.04) | 0.049 |
| TAMs (-: +) | 48.0 / 82.6 | 0.005 | 0.66 (0.18–2.39) | 0.520 |
| cTAMs (-: +) | 58.2 / 76.6 | 0.821 | ||
| mTAMs (-: +) | 52.0 / 79.9 | 0.031 | 0.77 (0.21–2.85) | 0.701 |
| < Primary tumor characteristics > | ||||
| Colon / rectum | 67.1 / 59.8 | 0.910 | ||
| Tumor differentiation (diff./ undiff.) | 64.3 / 25.0 | <0.001 | 0.02 (0.002–0.20) | <0.001 |
| T (2,3/4) | 74.4 / 35.2 | 0.040 | 0.62 (0.23–1.72) | 0.470 |
| Lymph node metastasis (-: +) | 75.6 / 83.9 | 0.442 | ||
| Lymphatic invasion (-: +) | 74.1 / 62.1 | 0.761 | ||
| Venous invasion (-: +) | 78.5 / 58.3 | 0.515 | ||
synch/ meta: synchronous/ metachronous, diff./undiff.: differentiated histological type/undifferentiated histological type.