Table 1.

	Longitudinal cohort (Webex) (N = 78)				Cross-sectional cohort (N = 35)
	Control group (n = 40)		Exercise group (n = 38)
	Baseline Mean (± SD)	Follow-up Mean (± SD)	Baseline Mean (± SD)	Follow-up Mean (± SD)	Mean (± SD)
Demographics
Age (y)	67.59 (9.71)		65.32 (10.08)		69.51 (8.77)
Men/Women (%)	8/32 (20/80)		10/28 (26/73)		10/25 (32/68)
BMI (kg/m2)	32.86 (7.80)		32.58 (7.50)		29.81 (5.12)	30.31 (7.26)
Endocannabinoids
2-AG	52.40 (42.12)	49.32 (32.13)	42.50 (28.85)	44.61 (30.48)	41.91 (36.81)
AEA	1.68 (.38)	1.53 (.26)	1.61 (.35)	1.79 (.44)**	.94 (.34)
OEA	7.18 (1.49)	7.15 (2.03)	6.71 (1.87)	7.37 (2.13)**	4.48 (1.78)
PEA	21.99 (33.22)	19.19 (16.99)	26.41 (24.14)	42.07 (31.18)**	26.03 (21.92)
Cytokines
INFγ	18.46 (17.91)	17.15 (15.63)	14.29 (10.80)	11.25 (7.30)	12.71 (8.12)
IL-10	1.02 (1.69)	.79 (.76)	.55 (.36)	.42 (.31) *	.67 (.53)
IL-13	3.44 (2.49)	2.91 (1.15)	3.26 (1.54)	1.81 (.98)**	3.18 (2.71)
IL-1	.34 (.45)	.22 (.15)	.28 (.27)	.18 (.09)	.41 (.39)
IL-4	.34 (.62)	.32 (.21)	.30 (.57)	.10 (.03)**	.15 (.09)
IL-6	3.16 (2.93)	2.82 (2.74)	2.67 (.86)	2.02 (.71)	1.42 (1.22)
IL-8	41.75 (35.62)	40.04 (35.84)	42.50 (2.21)	32.80 (2.20)	31.79 (17.19)
TNFα	7.05 (6.46)	6.44 (6.03)	7.78 (9.01)	5.91 (3.52)*	3.37 (.89)
SCFAs
Acetic acid	28.98 (17.89)	26.92 (16.45)	33.61 (18.43)	32.38 (17.12)	43.43 (68.69)
Butyric acid	11.04 (2.53)	10.63 (2.74)	10.86 (2.67)	17.23 (4.10)*	8.39 (.73)
Propionic acid	2.28 (5.98)	2.28 (6.17)	2.42 (6.57)	6.91 (2.03)*	10.13 (.79)
Valeric acid	3.21 (7.33)	2.92 (7.7)	3.20 (4.31)	3.38 (4.63)	1.25 (.52)
Iso-butyric acid	10.39 (2.90)	10.65 (3.09)	9.67 (2.35)	11.79 (3.47)*	10.69 (5.70)
Iso-valeric acid	5.69 (3.17)	5.95 (3.02)	5.55 (2.52)	5.61 (2.30)	7.26 (2.45)

BMI (Body Mass Index); SCFA (Short Chain Fatty Acids)

*p < .05; **p < .001. p values are FDR corrected obtained from paired matched t test between baseline and follow-up.