Figure 7: Schematics of transcytosis route through which NOGGIN (red) is trafficked from the apical to basolateral extracellular domain.
(Top) Schematics of hESC epithelium on filter (Bottom) Schematics of NOGGIN transcytosis route. Note that NOGGIN (red) travels through pinocytotic vesicles, ASE, EE, CRE, and BSE. ARE is shown in blue as it is not engaged in the trafficking of NOGGIN.