Table 1.
Baseline characteristics of neonates in the control, sepsis, and severe sepsis groups.
| Variables | Controls (n = 188) | Sepsis (n = 311) | Severe sepsis (n = 426) | p |
|---|---|---|---|---|
| Age (days) | 7.0 (5.0, 12.0) | 11.0 (5.0, 18.0)a | 10.0 (5.0, 16.0)b | <.001 |
| Male, n (%) | 115 (61.2%) | 193 (62.1%) | 260 (61.0%) | .958 |
| Weight (kg) | 3.3 ± 0.5 | 3.3 ± 0.6 | 3.1 ± 0.7bc | <.001 |
| Temperature (°C) | 36.9 ± 0.3 | 37.4 ± 0.7a | 37.3 ± 0.8b | <.001 |
| Respiratory (rate/minute) | 45.4 ± 6.3 | 49.1 ± 10.2a | 50.2 ± 11.5b | <.001 |
| Heart rate (bpm) | 141.8 ± 12.6 | 147.9 ± 18.7a | 151.0 ± 20.1b | <.001 |
| SBP (mm Hg) | 76.9 ± 7.2 | 79.1 ± 5.8a | 74.0 ± 9.2bc | <.001 |
| DBP (mm Hg) | 47.1 ± 7.5 | 47.4 ± 7.6 | 44.8 ± 8.2bc | <.001 |
| PCT (ng/ml) | 0.11 (0.09, 0.18) | 0.22 (0.11, 0.76)a | 0.42 (0.16, 2.24)bc | <.001 |
| hsCRP (mg/L) | 0.7 (0.7, 0.7) | 0.7 (0.7, 8.3)a | 0.7 (0.7, 17.2)bc | <.001 |
| nSOFA | 0.0 (0.0,0.0) | 0.0 (0.0,0.0) | 2.0 (0.0,3.0)bc | <.001 |
| Biochemical parameters | ||||
| TBIL (μM) | 306.4 (262.3, 357.7) | 132.0 (47.1, 226.4)a | 132.2 (43.9, 208.6)b | <.001 |
| AST (U/L) | 34.4 (28.5, 46.8) | 36.4 (27.9, 49.3) | 39.5 (28.0, 63.6)bc | <.001 |
| ALT (U/L) | 24.3 (17.6, 30.3) | 28.5 (22.2, 36.1)a | 28.4 (21.4, 39.9)b | <.001 |
| TP (g/L) | 57.5 ± 5.8 | 54.8 ± 6.2a | 53.6 ± 7.9b | <.001 |
| ALB (g/L) | 34.4 ± 3.7 | 31.4 ± 4.6a | 29.9 ± 5.0bc | <.001 |
| BUN (mM) | 2.2 (1.3, 2.9) | 2.8 (1.9, 4.0)a | 3.3 (2.0, 5.0)bc | <.001 |
| CREA (μM) | 49.6 (41.0, 57.9) | 44.6 (35.8, 55.6)a | 49.4 (38.5, 68.6)c | <.001 |
| UA (μM) | 135.5 (104.9, 186.5) | 146.3 (108.1, 191.3) | 152.6 (110.9, 219.3)b | .015 |
All Values are presented as the mean ± SD or n (%) or as the median (interquartile range). SBP: systolic blood pressure; DBP: diastolic blood pressure; PCT: procalcitonin; hsCRP: high sensitivity C-reactive protein; nSOFA: neonatal sequential organ failure assessment; TBIL: total bilirubin; AST: aspartate aminotransferase; ALT: alanine aminotransferase; TP: total protein; ALB: albumin; BUNA: blood urea nitrogen; CREA: creatinine; UA: uric acid. ap <.05 for sepsis vs. control. bp < .05 for severe sepsis vs. control. cp < .05 for severe sepsis vs. sepsis.