Table 2.
Clinical and demographic characteristics according to BUN tertiles.
| Variables | First tertile (<2.2) （n = 306） | Second tertile (2.2–3.6) （n = 312） | Third tertile (>3.6) （n = 307） | p |
|---|---|---|---|---|
| Age (days) | 9.0 (6.0, 15.0) | 11.0 (5.0, 17.0) | 8.0 (4.0, 14.0) | .001 |
| Male, n (%) | 198 (64.7%) | 190 (60.9%) | 180 (58.6%) | .296 |
| PCT (ng/ml) | 0.14 (0.09, 0.27) | 0.22 (0.12, 0.65) | 0.66 (0.20, 4.55) | <.001 |
| hsCRP (mg/L) | 0.7 (0.7, 1.2) | 0.7 (0.7, 8.2) | 0.7 (0.7, 17.3) | <.001 |
| Biochemical parameters | ||||
| TBIL (μM) | 200.4 (79.9, 293.2) | 156.6 (52.2, 279.7) | 162.4 (55.3, 258.5) | .037 |
| AST (U/L) | 32.8 (26.6, 43.1) | 37.5 (28.5, 50.3) | 44.6 (30.9, 72.8) | <.001 |
| ALT (U/L) | 26.0 (20.6, 32.6) | 27.1 (19.9, 36.2) | 29.6 (21.5, 46.5) | <.001 |
| TP (g/L) | 53.7 ± 6.0 | 55.3 ± 6.5 | 55.4 ± 8.8b | .004 |
| ALB (g/L) | 30.8 ± 4.4 | 31.7 ± 4.4 | 30.5 ± 5.9 | .077 |
| CREA (μM) | 45.0 (36.2, 54.3) | 44.3 (35.1, 56.9) | 60.2 (43.4, 84.6) | <.001 |
| UA (μM) | 115.3 (90.4, 149.6) | 141.7 (112.4, 185.3) | 201.6 (143.5, 319.9) | <.001 |
| nSOFA | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 2.0) | <.001 |
| Clinical data | ||||
| Con, n (%) | 89 (29.1%) | 72 (23.1%) | 27 (8.8%) | <.001 |
| Sepsis, n (%) | 100 (32.7%) | 114 (36.5%) | 97 (31.6%) | .392 |
| Severe sepsis, n (%) | 117 (38.2%) | 126 (40.4%) | 183 (59.6%) | <.001 |
All values are presented as the mean ± SD or n (%) or as the median (interquartile range). PCT: procalcitonin; hsCRP: high sensitivity C-reactive protein; TBIL: total bilirubin; AST: aspartate aminotransferase; ALT: alanine aminotransferase; TP: total protein; ALB: albumin; BUN: blood urea nitrogen; CREA: creatinine; UA: uric acid; nSOFA: neonatal sequential organ failure assessment.