Table 2.

Summary of criteria for levels of evidence reported in the Can-SCIP guideline.

Grade of recommendation	Descriptor
A	Recommendation supported by at least 1 meta-analysis, systematic review, or randomized controlled trial of appropriate size with relevant control group.
B	Recommendation supported by cohort studies that at minimum have a comparison group, well-designed single-subject experimental designs, or small sample size randomized controlled trials.
C	Recommendations supported primarily by expert opinion based on their experience through uncontrolled case series without comparison groups that support the recommendations are also classified here.

Notes: Adapted from Hebert et al.⁴⁰