Comparison of (a) DeepAtrophy predicted interscan interval (PII), (b) Automatic Longitudinal Hippocampal Atrophy software/package (ALOHA) volume change, and (c) Preclinical Alzheimer’s Cognitive Composite (PACC) score change for individual subjects for all available scans. For DeepAtrophy, the predicted interscan interval, as an indicator of brain change, is expected to be above zero. For ALOHA and PACC, the volume/score change is expected to be below zero to represent brain atrophy/cognitive decline. Abbreviations: A+/A− = beta-amyloid positive/negative; NC = cognitively normal adults; eMCI = early mild cognitive impairment; lMCI = late mild cognitive impairment.