Table 1.
Characteristics of the selected ADNI2/GO participants whose T1-weighted MRI scans were used for the DeepAtrophy and ALOHA experiments. All subjects had 2 to 6 scans between 0.25 and 5.5 years from the baseline. The split of the dataset into training and test subsets across five cross-validation experiments is detailed in Supplemental Table S1. Abbreviations: n = number of subjects; A+/A− = beta-amyloid positive/negative; NC = cognitively normal adults; eMCI = early mild cognitive impairment; lMCI = late mild cognitive impair; Edu = years of education; MMSE = Mini-Mental State Examination; ALOHA = Automatic Longitudinal Hippocampal Atrophy software/package; F = female; M = male.
| A− NC (n = 171) | A+ NC (n = 83) | A+ eMCI (n = 133) | A+ lMCI (n = 105) | |
|---|---|---|---|---|
| Age (years) | 72.1 (6.1) | 75.4 (5.8)**** | 73.8 (7.0)* | 72.3 (6.7) |
| Sex | 86F 85M | 56F 27M | 54F 79M | 50F 55M |
| Edu (years) | 16.9 (2.4) | 16.1 (2.7)* | 15.8 (2.9)*** | 16.6 (2.6) |
| MMSE | 29.1 (1.3) | 29.0 (1.1) | 28.0 (1.6)**** | 27.0 (1.9)**** |
Notes:
, p < 0.05;
, p < 0.01;
, p < 0.001;
, p < 0.0001.
Independent two-sample t-test (continuous variables with normal distribution, for age and education), Mann–Whitney U test (continuous variable with non-normal distribution, for MMSE) and contingency χ2 test (for sex) were performed. All statistical comparisons are with the A− NC group. Standard deviation is reported in parenthesis.