Table 3.

Comparison of relative inter-scan interval (RISI) inference accuracy for DeepAtrophy and ALOHA. Given two pairs of scans from the same subject of different interscan-intervals, a method sensitive to underlying biological change should be able to correctly detect which scan pair has a longer inter-scan interval. Abbreviations: ALOHA = Automatic Longitudinal Hippocampal Atrophy software/package; A+/A− = beta-amyloid positive/negative; NC = cognitively normal adults; eMCI = early mild cognitive impairment; lMCI = late mild cognitive impairment.

	A− NC	A+ NC	A+ eMCI	A+ lMCI	All Groups
ALOHA	68.8%	72.7%	76.3%	83.4%	75.0%
DeepAtrophy	79.3%	81.5%	81.3%	83.3%	81.1%