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. 2021 Nov 12;2021:3827501. doi: 10.1155/2021/3827501

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Copyright © 2021 Binbin Zheng et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Lidocaine significantly inhibited LPS-induced expression of tissue factor (TF) and matrix metalloproteinase (MMP)-2/9 in the lung tissues from mice. Representative Western blot images showed the levels of p-ASK1 (a), p-p38 (b), TF (c), and HIF-1α (d) in lung tissues. (e, f) Activity of MMP-2/9 in lung tissues was measured by gelatin zymography, and the densitometry values were normalized. Mice were treated with different dosages of lidocaine (2, 4, and 8 mg/kg, i.v.) 30 min before LPS injection, and the tissue samples (n = 4 of each group) were collected 12 h after LPS given. Significant difference was revealed following one-way or two-way ANOVA (^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001 vs. control; ^#P < 0.05 and ^##P < 0.01 vs. LPS-treated group; Bonferroni post hoc tests).