Table 2.

Nuclear morphological characteristics of the invasive breast cancer with three groups.

Characteristics	Cases			P value
	HR+/HER2-	HR-/HER2+	HR-/HER2-	HR+/HER2- vs. HR-/HER2+	HR+/HER2- vs. HR-/HER2-	HR-/HER2+ vs. HR-/HER2-
Nuclear/cytoplasmic ratio				0.317	0.610	1.000
≤1	82	51	22
> 1	4	5	2
Difference of nuclear size				<0.001	0.068	0.033
MAX/MIN ≤ 2	84	35	21
MAX/MIN > 2	2	21	3
Nuclear pleomorphism				<0.001	0.218	0.267
Mild-moderate	86	47	23
Severe	0	9	1
Chromatin feature				0.202	0.558	0.781∗
Fine-powder	82	42	19
Granular	4	14	5
Nuclear membrane				0.314∗	1.000∗	0.523∗
Absent or few	21	18	6
Conspicuous	65	38	18
Nucleoli				<0.001	0.053	0.189
Absent or few	33	3	4
Conspicuous	53	53	20
Nucleolar size				<0.001	<0.001	0.373
Micro	44	9	2
Medium	9	36	12
Large	0	8	6
Nucleolar number				<0.001	<0.001	1.000
1	16	49	19
2	18	4	1
≥ 3	19	0	0
Histological grade				<0.001	0.019	<0.001
I	19	0	0
II	59	30	22
III	8	26	2
Tubule formation				0.075	<0.001	0.090
1	5	0	0
2	19	19	13
3	62	37	11
Pleomorphism				<0.001	<0.001	<0.001
1	28	0	0
2	54	20	20
3	4	36	4
Mitotic counts				<0.001	0.004	0.668
1	23	0	0
2	57	50	23
3	6	6	1

Nucleolar size: micro (average diameter ≤ 1 μm), medium (1 μm < average diameter ≤ 2 μm), and large (average diameter > 2 μm).