Table 3.
Relationship Between Plasma tHcy Levels and Mean CTFC Levels in Different Models
| Variables | Crude Model | Model I | Model II | |||
|---|---|---|---|---|---|---|
| β (95% CI) | P-value | β (95% CI) | P-value | β (95% CI) | P-value | |
| tHcy (μmol/L) | ||||||
| Per 1 increase | 0.42 (0.25, 0.59) | <0.001 | 0.37 (0.20, 0.54) | <0.001 | 0.45 (0.29, 0.65) | <0.001 |
| Per SD increase | 1.75 (1.05, 2.44) | <0.001 | 1.54 (0.85, 2.24) | <0.001 | 1.96 (1.20, 2.73) | <0.001 |
| tHcy (μmol/L) | ||||||
| <10 | Ref | Ref | Ref | |||
| ≥10 | 3.60 (1.41, 5.78) | 0.002 | 3.14 (1.03, 5.25) | 0.005 | 3.35 (1.01, 5.69) | 0.006 |
| tHcy (μmol/L) | ||||||
| <15 | Ref | Ref | Ref | |||
| ≥15 | 2.68 (1.22, 4.14) | <0.001 | 2.22 (0.76, 3.68) | 0.004 | 2.89 (1.35, 4.43) | <0.001 |
| tHcy tertiles (μmol/L) | ||||||
| T1 [5.76, 13.04] | Ref | Ref | Ref | |||
| T2 [13.09, 16.50] | 1.46 (−0.25, 3.18) | 0.098 | 1.05 (−0.66, 2.75) | 0.233 | 1.92 (0.03, 3.80) | 0.050 |
| T3 [16.92, 26.85] | 4.18 (2.48, 5.88) | <0.001 | 3.54 (1.79, 5.29) | <0.001 | 4.20 (2.37, 6.02) | <0.001 |
| P for trend | <0.001 | <0.001 | <0.001 | |||
| tHcy quartiles (μmol/L) | ||||||
| Q1 [5.76, 12.30] | Ref | Ref | Ref | |||
| Q2 [12.44, 14.24] | 1.61 (−0.40, 3.61) | 0.120 | 1.24 (−0.72, 3.20) | 0.218 | 1.40 (−0.61, 3.41) | 0.176 |
| Q3 [14.25, 17.38] | 2.14 (0.14, 4.15) | 0.039 | 1.65 (−0.32, 3.62) | 0.104 | 2.52 (0.39, 4.65) | 0.023 |
| Q4 [17.45, 26.85] | 4.66 (2.70, 6.62) | <0.001 | 4.07 (2.10, 6.04) | <0.001 | 5.07 (2.98, 7.16) | <0.001 |
| P for trend | <0.001 | <0.001 | <0.001 | |||
Notes: Model I adjusted for age and sex. Model II adjusted for sex, HR, SBP, Killip classification, hypertension, diabetes mellitus and eGFR.
Abbreviations: tHcy, total homocysteine; CTFC, corrected thrombolysis in myocardial infarction frame count; Ref, reference; β, effect size; CI, confidence interval; SD, standard deviation.