Table 3.
Nine Genes Enriched in 3 Pathways
| Gene | Function | Pathway | Trend (TB/HC)* | AUC |
|---|---|---|---|---|
| SDS | Serine dehydratase | Valine, leucine, and isoleucine biosynthesis | ↓ | 0.981 (0.930–1.000) |
| SDSL | Serine dehydratase like | Valine, leucine, and isoleucine biosynthesis | ↓ | 1.000 (1.000–1.000) |
| BCAT1 | Branched chain amino acid transaminase 1 | Valine, leucine, and isoleucine biosynthesis | ↓ | 1.000 (1.000–1.000) |
| BCAT2 | Branched chain amino acid transaminase 2 | Valine, leucine, and isoleucine biosynthesis | ↑ | 0.852 (0.635–1.000) |
| GLYAT | Glycine-N-acyltransferase | Phenylalanine metabolism | ↑ | 1.000 (1.000–1.000) |
| ALDH3B1 | Aldehyde dehydrogenase 3 family member B1 | Phenylalanine metabolism | ↑ | 0.981 (0.930–1.000) |
| IL4I1 | Interleukin 4 induced 1 | Phenylalanine metabolism; Phenylalanine, tyrosine, and tryptophan biosynthesis | ↓ | 1.000 (1.000–1.000) |
| GOT1 | Glutamic-oxaloacetic transaminase 1 | Phenylalanine metabolism | ↓ | 1.000 (1.000–1.000) |
| MIF | Macrophage migration inhibitory factor | Phenylalanine metabolism | ↑ | 0.963(0.877–1.000) |
Notes: *The trend of marker levels in the active TB group. ↑ and ↓ indicate increased and decreased levels, respectively, compared with the healthy group.
Abbreviation: TB, tuberculosis.