The genomic structure of HERVs. The general structure of a full-length HERV provirus is represented: the two long terminal repeats (LTRs) flank the gag, pro, pol, and env genes that encoded matrix, capsid, nucleocapsid; proteinase, reverse transcriptase, integrase; and envelop, respectively. Although full-length HERVs exist, HERVs DNA sequences are often truncated, and contain mutations, insertions, or deletions.