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. 2021 Oct 25;297(5):101344. doi: 10.1016/j.jbc.2021.101344

Figure 7.

Figure 7

Neuropathology of mice inoculated with WT, Met4-1, or ΔN6 recPrPSc.A, brain sections were stained with HE, anti-Iba-1 antibody, anti-GFAP antibody, and SAF-84 anti-PrP antibody as indicated. The scale bar represents 200 μm. B, scores of vacuolization of various brain regions of mice inoculated with WT, Met4-1, and ΔN6 recPrPSc. The following brain regions were examined: cerebellum white matter (CWM), septal nuclei (Sep-N), frontal cortex (FC), hippocampus (HP), hypothalamus (HT), midbrain (MB), medulla (MD), pons (P), and thalamus (TH). C, average vacuolation scores of CWM, FC, and P brain regions of mice inoculated with WT, Met4-1, or ΔN6 recPrPSc (n = 3). Statistical significance was determined by two-way ANOVA followed by Tukey's multiple comparison test. ∗ represents p < 0.05; ∗∗∗ represents p < 0.01. Error bars indicate standard deviation. recPrP, recombinant PrP.