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. 2021 Nov 9;48:102182. doi: 10.1016/j.redox.2021.102182

Fig. 2.

Fig. 2

Cognitive behaviors in miR-455-3p TG and KO mice. (A) Mice cognitive behavior analysis using Morris Water Maze (MWM) test. Representative mice body tracking plots showing mouse movement to find the platform in WT control, TG and KO mice. Average heat map of MWM trials in WT (n = 15), TG (n = 15) and KO (n = 15) mice showing mice locations during the test to find the platform. (B) Latency to find the platform by WT mice, miR-455-3p TG and miR-455-3p KO mice. Average time (in seconds) to find the platform was significantly lower in TG mice relative to WT (P = 0.037) and KO mice (P = 0.003). KO mice spent more time to find the platform compared to WT mice. (C) Total distance travelled (in meters) to find the platform by WT, TG and KO mice. The TG mice travelled significantly minimum distance compared to WT (P = 0.016) and KO (P = 0.003) while KO mice traveled maximum distance to find the platform compared to WT (P = 0.008). (D) Average time spent (in seconds) in the target quadrant that has the platform by WT, TG and KO mice. TG mice spent significantly maximum time in the target quadrant compared to WT (P = 0.015) and KO mice (P = 0.003). While KO mice spent minimum time in the target quadrant compared to WT mice (P = 0.020).