Table 1.
AUCs of different methods based on LDpred in the Welcome Trust Case Control Consortium Dataset.
| Trait | LDpred | LDpred+STRS (p-valuea) | LDpred+MTRS (p-valueb) |
|---|---|---|---|
| Bipolar disorder | 0.6574 | 0.6605 (0.031) | 0.6626 (0.004) |
| Coronary artery disease | 0.5965 | 0.5990 (0.033) | 0.5998 (0.005) |
| Crohn’s disease | 0.6293 | 0.6336 (9.073 × 10−4) | 0.6348 (1.013 × 10−4) |
| Hypertension | 0.5856 | 0.5890 (0.008) | 0.5915 (3.237 × 10−4) |
| Rheumatoid arthritis | 0.6561 | 0.6590 (0.017) | 0.6465 (1) |
| Type 1 diabetes | 0.7868 | 0.8027 (6.761 × 10−15) | 0.7709 (1) |
| Type 2 diabetes | 0.5985 | 0.6009 (0.034) | 0.6027 (0.002) |
Abbreviations: AUC, area under the curve; STRS, single-tissue transcriptional risk score; MTRS, multi-tissue transcriptional risk score.
a
p-value is based on the bootstrap test of comparing LDpred+STRS with LDpred across 100 stratified bootstrap replicates.
b
p-value is based on the bootstrap test of comparing LDpred+MTRS with LDpred across 100 stratified bootstrap replicates.