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. Author manuscript; available in PMC: 2022 Nov 19.
Published in final edited form as: ACS Chem Biol. 2021 Sep 20;16(11):2268–2279. doi: 10.1021/acschembio.1c00427

Figure 1.

Figure 1.

Proline catabolism and PRODH inhibitors. (A) The enzymes and reactions of proline catabolism. (B) Structures of a reversible PRODH inhibitor (1) and four covalent inactivators, which modify the N5 of PRODH (2 - 5).