Table 2.
A-T patients from the Frankfurt cohort
| All patients | no deficient IgA (IgA ≥ 0.07 g/L) | IgA deficient (IgA < 0.07 g/L) | P value | |
|---|---|---|---|---|
| No. of patients (n) | 66 | 31 | 35 | – |
| Age (years) | 12 (1–39) | 15 (2–39) | 10 (1–38) | n.s |
| Sex (M/F) | 35/31 | 16/15 | 19/16 | – |
| IgA (g/L) | 0.06 (0.002–2.25) | 11.0 (0.3–2.25) | 0.05 (0.002–0.06) | 0.0001 |
| IgG (g/L) | 8.70 (0.66–21.5) | 8.34 (3.96–21.5) | 9.01 (0.66–20.6) | n.s |
| IgG2 (g/L) | 0.69 (0.11–6.98) | 0.64 (0.12–2.76) | 0.82 (0.11–6.98) | n.s |
| IgG4 (g/L) | 0.02 (0.00–0.42) | 0.03 (0.00–0.42) | 0.02 (0.00–0.23) | n.s |
| IgM (g/L) | 1.53 (0.17–5.45) | 1.67 (0.72–5.45) | 1.19 (0.17–2.73) | n.s |
| Lymphocytes (cells/µL) | 1335 (180–3660) | 1608 (595–3660) | 1142 (180–2700) | 0.01 |
| α-feto-protein (ng/mL) | 278 (28.7–1264) | 266 (28.7–1264) | 332 (49–1044) | n.s |
| CRP§ | 18 | 4 | 14 | 0.05 |
| Granulomas | 8 | 1 | 7 | 0.058 |
* included patients with partial IgA-D (n = 7), all of them aged above 12 years of age and an IgA level > 0.3 g/L. § number of episodes with a significant elevation of CRP > 2 mg/dL