Table 2.
AUC ratios of minimal vs full PBPK model simulations
| Mouse | Rat | NHP | Human | |
|---|---|---|---|---|
| Plasma | 0.96 | 1.00 | 1.06 | 1.05 |
| ISF | 0.94 | 1.00 | 1.06 | 1.04 |
| CSF (LV) | 1.17 | 1.19 | 1.22 | 1.21 |
| CSF (SAS) | 0.96 | 1.00 | 1.06 | 1.04 |
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