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. 2021 Oct 17;41(8):1915–1935. doi: 10.1007/s10875-021-01141-0

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© The Author(s) 2021

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Fig. 2 — ADA2 mutations impede B cell development in the bone marrow at the preB to immature B cell stage. A, B BM aspirates from healthy donors, or a DADA2 patient were labeled with mAbs against CD34, CD19, CD20, CD10, IgM and IgD. A Proportions of B-lineage cells (CD19⁺), pro-B (CD19⁺CD34⁺CD10^hi), pre-BI (CD19⁺CD34⁻CD10^hi), pre-BII (CD19⁺CD34⁻CD10^hi), immature (CD19⁺CD34⁻CD10^int) and recirculating mature (CD19⁺CD34⁻CD10⁻CD20⁺) B cells. B Each BM B cell subset in healthy donors (black histogram) and DADA2 patients (red histogram) was assessed for expression of IgM (upper) and IgD (lower panel). Values in B correspond to the gMFI of IgM and IgD expression on BM B cell subsets from in healthy donors (black) and the DADA2 patient (red)