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. 2021 Nov 19;5:97. doi: 10.1038/s41698-021-00236-6

Fig. 5. Tumors with high CD8+FOXP3−/FOXP3+ ratio show upregulation of ECM-integrin interaction pathways in our UUS cohort.

Fig. 5

a Metascape pathway analysis reveals the most significantly altered pathways in the CFRHigh group (CD8+FOXP3−/FOXP3+ >1) and their interactions. b MCODE-identified neighborhoods of densely connected proteins based on upregulated genes in the high CFR group showing their corresponding enriched Gene Ontologies. c Heat map of gene expression of significantly altered genes in the CFR-defined groups with patient clustering indicating their corresponding ECM signature as defined by Binzer-Panchal et al. d Ingenuity pathway analysis (IPA) indicates the potential upstream regulators of the differential gene expression between CFR high and low tumors. e Connectivity Map analysis shows potential gene expression-altering drugs for the upregulated genes in the CFRHigh compared to CFRLow groups. f Expression of 22 YAP-TEAD target genes in CFR groups and Low TILs. Significance is indicated as *(P < 0.05), **(P < 0.01), ***(P < 0.001).