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. 2021 Nov 19;12:6749. doi: 10.1038/s41467-021-27001-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Partitioned LD score regression of ESC, HP, and HN cRE against the indicated genome-wide signal. Circle size indicates the enrichment of estimated heritability, and color indicates statistical significance. b Proportion of genes from our variant-to-gene mapping located in each DE cluster (Fig. 2a) or non-DE genes (black). c Comparison of genes implicated in our variant-to-gene mapping analysis for each GWAS. Dots and lines indicate the intersect of the set of genes found in each GWAS. Top: the number of genes in different overlapping sets. Right: the number of SNPs detected in each GWAS. d FEZF1 genomic locus with interactions connecting to a distal cRE. The SNP is located in a putative NRF1 motif. e Genome track for the BDNF locus. Multiple proxies in open regions are shown. Two proxies located in putative TF motifs for CUX1/2 and MAF::NFE2 are shown.