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. 2021 Nov 19;7:144. doi: 10.1038/s41523-021-00352-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Correlation matrix of the different variables derived from multiplex fluorescent IHC, manual and digital TILs scoring; Correlations of easTILs in whole-slide images (b) and TMA (c) with manual TILs scoring in lymphocyte-predominant breast cancer (LPBC) and non-LPBC; Correlation between CD4 and CD8 stromal (d) and intra-tumoral (e) immune cell subsets with LPBC and non-LPBC based on manual TILs scoring.; In the boxplots, each box extends from the 25th to the 75th percentile, the midline represents the median, and the whiskers extend from –1.5 × IQR to +1.5 × IQR from the closest quartile, where IQR is the inter-quartile range; WSI: whole-slide images, TMA: tissue microarrays.