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. 2021 Nov 19;4:1312. doi: 10.1038/s42003-021-02844-1

Fig. 4. Effect of piR-39980 on DOX sensitivity of the resistant HT1080/DOX cells.

Fig. 4

a Transfection efficiency showing relative expression of piR-39980 increased by ~250-fold in HT1080/DOX cells transfected with 20 nM piR-39980 mimics compared to controls. Bars, mean ± SEM; n = 3 independent experiments; ns nonsignificant, *P < 0.05, Tukey’s multiple comparisons test. b Effect of piR-39980 on HT1080/DOX cell viability determined by MTT assay. Bars, mean ± SEM; n = 3 independent experiments; ns nonsignificant, *P < 0.05, **P < 0.01, Tukey’s multiple comparisons test. c The colony-forming ability of HT1080/DOX cells transfected with piR-39980 mimic. Bars, mean ± SEM; n = 3 independent experiments; ns non-ignificant, *P < 0.05, **P < 0.01, Tukey’s multiple comparisons test. d Effect of piR-39980 on HT1080/DOX cell morphology upon 0.4 µM DOX treatment. Scale bar: 100 μm.