TABLE 1.
Association of FABP4 expression with clinical characteristics and selected biological markers of GIST
| Groups | No. | Low or no expression (%) | High expression (%) | p Value |
|---|---|---|---|---|
| Total | 125 | 88 (70.40) | 37 (29.60) | |
| Gender | ||||
| Female | 61 | 44 (72.13) | 17 (27.87) | 0.679 |
| Male | 64 | 44 (68.75) | 20 (31.25) | |
| Age (years) | ||||
| ≦60 | 62 | 43 (69.35) | 19 (30.65) | 0.800 |
| >60 | 63 | 45 (71.43) | 18 (28.57) | |
| Tumor size (cm) | ||||
| <5 | 35 | 30 (85.71) | 5 (14.29) | 0.002* |
| 5–10 | 58 | 43 (74.14) | 15 (25.86) | |
| ≧10 | 32 | 15 (46.88) | 17 (53.12) | |
| Mitotic index (per 50 HPFs) | ||||
| 0–5 | 59 | 52 (88.14) | 7 (11.86) | <0.001* |
| 6–10 | 38 | 25 (65.79) | 13 (34.21) | |
| >10 | 28 | 11 (39.29) | 17 (60.71) | |
| Number of lesions | ||||
| Single nodule | 117 | 83 (70.94) | 34 (29.06) | 0.613 |
| Multiple nodules | 8 | 5 (62.50) | 3 (37.50) | |
| Tumor location | ||||
| Stomach | 58 | 44 (75.86) | 14 (24.14) | 0.370 |
| Intestine | 47 | 32 (68.09) | 15 (31.91) | |
| Others | 20 | 12 (60.00) | 8 (40.00) | |
| AFIP‐Miettinen risk | ||||
| Very low–Moderate risk | 73 | 60 (82.19) | 13 (17.81) | 0.001* |
| High risk | 52 | 28 (53.85) | 24 (46.15) | |
*p < 0.05.
Abbreviations: FABP4, fatty acid‐binding protein 4; GIST, gastrointestinal stromal tumors; HPFs, high‐power fields.