TABLE 2.
Genotype and allele frequencies of ‐794 CATT5‐8 and ‐173 G>C MIF polymorphisms in PP patients and CS
| Polymorphism | PP n = 224% (n) | CS n = 232% (n) | OR (CI 95%) | p Value ‡ , † |
|---|---|---|---|---|
| MIF ‐794 CATT5‐8 (rs5844572) | ||||
| Genotype | ||||
| 5,5 | 3.5 (8) | 3 (6) | 1.47 (0.421–5.403) | 0.49 |
| 5,6 | 25 (56) | 29 (68) | 0.91 (0.544–1.510) | 0.69 |
| 5,7 | 9.5 (22) | 5 (12) | 2.02 (0.880–4.822) | 0.07 |
| 5,8 | 0.5 (1) | ‐ | ‐ | ‐ |
| 6,6 § , ¶ | 31 (69) | 33 (76) | 1 | ‐ |
| 6,7 | 23 (51) | 23 (54) | 1.04 (0.615–1.770) | 0.88 |
| 6,8 | 0.5 (1) | 1 (2) | 0.55 (0.010–10.830) | 0.62 |
| 7,7 | 7 (16) | 6 (14) | 1.26 (0.534–3.012) | 0.57 |
| Allele | ||||
| 5 | 21 (95) | 20 (92) | 1.16 (0.820–1.640) | 0.39 |
| 6 § , ¶ | 55 (246) | 59.5 (276) | 1 | ‐ |
| 7 | 23.5 (105) | 20 (94) | 1.25 (0.891–1.763) | 0.17 |
| 8 | 0.5 (2) | 0.5 (2) | ‐ | ‐ |
| MIF ‐173 G>C (rs755622) | ||||
| Genotype | ||||
| GG § , ¶ | 48 (107) | 58 (135) | 1 | ‐ |
| GC | 44 (99) | 35 (82) | 1.51 (1.026–2.228) | 0.03 |
| CC | 8 (18) | 7 (15) | 1.51 (0.724–3.121) | 0.26 |
| Allele | ||||
| G § , ¶ | 70 (313) | 76 (352) | 1 | ‐ |
| C | 30 (135) | 24 (112) | 1.34 (1.005–1.807) | 0.04 |
| Genetic models | ||||
| Dominant | ||||
| GG § , ¶ | 48 (107) | 58 (135) | 1 | ‐ |
| GC+CC | 52 (117) | 42 (97) | 1.51 (1.043–2.187) | 0.02 |
| Recessive | ||||
| GG+GC § , ¶ | 92 (206) | 93 (217) | 1 | |
| CC | 8 (18) | 7 (15) | 1.25 (0.618–2.563) | 0.52 |
Abbreviations: PP, plaque psoriasis patients; CS, control subjects; OR, odds ratio; CI, confidence interval.
†
Chi‐square test.
¶
Reference category.
Bold values denote statistical significance at the p < 0.05 level.