Table 2b.
DAVID analysis for genes of SCK-cryopreserved hiPS cells classified under ‘apoptosis’ with a difference in expression of more than 1.5-fold compared with non-frozen hiPS cells (p < 0.05).
| No. | Category | Term | Count | % | PValue | Genes | List Total | Pop Hits | Pop Total | Fold Enrichment | Bonferroni | Benjamini | FDR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GOTERM_BP_DIRECT | GO:0008630∼intrinsic apoptotic signaling pathway in response to DNA damage | 3 | 23.1 | 3.40E-04 | IKBKE BCL2A1 MLH1 | 11 | 47 | 16792 | 97.44 | 0.079 | 0.083 | 0.082 |
| 2 | GOTERM_BP_DIRECT | GO:0043066∼negative regulation of apoptotic process | 4 | 30.8 | 0.002 | BIRC3 FAIM BCL2A1 WT1 | 11 | 455 | 16792 | 13.42 | 0.394 | 0.231 | 0.229 |
| 3 | GOTERM_BP_DIRECT | GO:0006915∼apoptotic process | 4 | 30.8 | 0.004 | BIRC3 FAIM CASP6 STK17B | 11 | 567 | 16792 | 10.77 | 0.608 | 0.231 | 0.229 |
| 4 | GOTERM_BP_DIRECT | GO:0051260∼protein homooligomerization | 3 | 23.1 | 0.005 | IKBKE CAV1 BID | 11 | 177 | 16792 | 25.87 | 0.682 | 0.231 | 0.229 |
| 5 | GOTERM_BP_DIRECT | GO:0060546∼negative regulation of necroptotic process | 2 | 15.4 | 0.005 | BIRC3 CAV1 | 11 | 8 | 16792 | 381.64 | 0.686 | 0.231 | 0.229 |
| 6 | GOTERM_BP_DIRECT | GO:0042981∼regulation of apoptotic process | 3 | 23.1 | 0.007 | BIRC3 BID CASP6 | 11 | 213 | 16792 | 21.50 | 0.807 | 0.273 | 0.271 |
| 7 | GOTERM_BP_DIRECT | GO:0043065∼positive regulation of apoptotic process | 3 | 23.1 | 0.013 | BCL2A1 BID WT1 | 11 | 300 | 16792 | 15.27 | 0.959 | 0.402 | 0.399 |
| 8 | GOTERM_BP_DIRECT | GO:0001836∼release of cytochrome c from mitochondria | 2 | 15.4 | 0.014 | BCL2A1 BID | 11 | 23 | 16792 | 132.74 | 0.964 | 0.402 | 0.399 |
| 9 | GOTERM_BP_DIRECT | GO:2001238∼positive regulation of extrinsic apoptotic signaling pathway | 2 | 15.4 | 0.015 | CAV1 BID | 11 | 26 | 16792 | 117.43 | 0.977 | 0.402 | 0.399 |
| 10 | GOTERM_BP_DIRECT | GO:0035666∼TRIF-dependent toll-like receptor signaling pathway | 2 | 15.4 | 0.017 | IKBKE BIRC3 | 11 | 28 | 16792 | 109.04 | 0.983 | 0.402 | 0.399 |
| 11 | GOTERM_BP_DIRECT | GO:2001244∼positive regulation of intrinsic apoptotic signaling pathway | 2 | 15.4 | 0.019 | CAV1 BID | 11 | 33 | 16792 | 92.52 | 0.992 | 0.430 | 0.427 |
| 12 | GOTERM_BP_DIRECT | GO:0006468∼protein phosphorylation | 3 | 23.1 | 0.029 | IKBKE PRKCA STK17B | 11 | 456 | 16792 | 10.04 | 0.999 | 0.580 | 0.576 |
| 13 | GOTERM_BP_DIRECT | GO:0001570∼vasculogenesis | 2 | 15.4 | 0.033 | CAV1 WT1 | 11 | 56 | 16792 | 54.52 | 1.000 | 0.593 | 0.588 |
| 14 | GOTERM_BP_DIRECT | GO:0031398∼positive regulation of protein ubiquitination | 2 | 15.4 | 0.037 | BIRC3 CAV1 | 11 | 64 | 16792 | 47.70 | 1.000 | 0.593 | 0.588 |
| 15 | GOTERM_BP_DIRECT | GO:0038061∼NIK/NF-kappaB signaling | 2 | 15.4 | 0.039 | IKBKE BIRC3 | 11 | 66 | 16792 | 46.26 | 1.000 | 0.593 | 0.588 |
| 16 | GOTERM_BP_DIRECT | GO:0030855∼epithelial cell differentiation | 2 | 15.4 | 0.041 | WT1 CASP6 | 11 | 70 | 16792 | 43.62 | 1.000 | 0.593 | 0.588 |
| 17 | GOTERM_BP_DIRECT | GO:0097190∼apoptotic signaling pathway | 2 | 15.4 | 0.041 | PRKCA CAV1 | 11 | 71 | 16792 | 43.00 | 1.000 | 0.593 | 0.588 |
| 18 | KEGG_PATHWAY | hsa04210:Apoptosis | 3 | 23.08 | 0.002 | BIRC3 BID CASP6 | 9 | 62 | 6879 | 36.98 | 0.163 | 0.177 | 0.177 |
| 19 | KEGG_PATHWAY | hsa05200:Pathways in cancer | 4 | 30.77 | 0.008 | BIRC3 PRKCA BID MLH1 | 9 | 393 | 6879 | 7.78 | 0.497 | 0.342 | 0.342 |
| 20 | KEGG_PATHWAY | hsa04510:Focal adhesion | 3 | 23.08 | 0.022 | BIRC3 PRKCA CAV1 | 9 | 206 | 6879 | 11.13 | 0.841 | 0.606 | 0.606 |