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. 2021 Nov 11;5(1):e202101168. doi: 10.26508/lsa.202101168

Figure 2. SARS-CoV-2 infection induces elevation of GSL levels in vitro.

Figure 2.

Vero E6 cells were infected with SARS-CoV-2 at a MOI of 5, and SL levels were quantified at 3 hpi by LC–MS. DHCer, dihydroceramide; Cer, ceramide; HexCer, hexosylceramide; LacCer, lactosylceramide; DHSM, dihydrosphingomyelin; SM, sphingomyelin; C1P, ceramide-1-phosphate. Data are the means of four biological replicates ± SEMs. Statistical analysis was performed using a two-tailed unpaired t test. P-values are indicated by asterisks, as follows: *P < 0.05, **P < 0.01, and ***P < 0.001. Differences with a P-value of 0.05 or less were considered significant. Graphs were generated using GraphPad Prism software version 8.4.3. Complete dataset in Table S1.