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. 2021 Nov 11;5(1):e202101168. doi: 10.26508/lsa.202101168

Figure 4. Treatment with GZ-346 prevents the elevation in the levels of HexCer and gangliosides upon SARS-CoV-2 infection in vitro.

Figure 4.

Vero E6 cells were infected with SARS-CoV-2 at a MOI of 5 with or without GZ-346 (10 μM). GZ-346 was added to the medium 1 h before infection. Cer, ceramide; HexCer, hexosylceramide; LacCer, lactosylceramide; SM, sphingomyelin; GA1, asialo GM1; GA2, asialo GM2. Data are the means of four biological replicates ± SEMs. Statistical analysis was performed using one-way ANOVA followed by Tukey’s multiple comparison test. P-values are indicated by asterisks, as follows: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. Differences with a P-value of 0.05 or less were considered significant. Graphs and analysis were performed using GraphPad Prism software version 8.4.3. Complete dataset in Table S1.