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. 2021 Nov 11;5(1):e202101168. doi: 10.26508/lsa.202101168

Figure 5. SARS-CoV-2 infection induces elevation in sphinganine levels in murine serum.

Figure 5.

K18-hACE2 transgenic mice were infected with SARS-CoV-2 (20 pfu, intranasally inoculated, n = 5) or uninfected (control, n = 4). Sphingoid base levels in serum samples obtained at day 5 post infection were analyzed by LC–MS. 3KSa, 3-ketosphinganine; Sa, sphinganine; So, sphingosine; Sa1P, sphinganine-1-phosphate; S1P, sphingosine-1-phosphate. Data are means± SEMs. Statistical analysis was performed using a two-tailed unpaired t test. P-values are indicated by asterisks, as follows: *P < 0.05, and ****P < 0.0001. Differences with a P-value of 0.05 or less were considered significant. Graphs were generated using GraphPad Prism software version 8.4.3. Complete dataset in Table S3.