(A) Body weight (% of infection day 0) of five K18-hACE2 mice infected with SARS-CoV-2 (20 pfu, intranasal). Serum for sphingolipid analysis was taken at 5 dpi (marked by arrow). Mice 1–3 succumbed to death (nonsurvivors). Mice 4–5 survived (survivors). (B) Detailed presentation of selected sphingolipid levels divided into two subgroups of infected mice: survivors and nonsurvivors. Sa, sphinganine; So, sphingosine; C1P, ceramide-1-phosphate; DHSM, dihydrosphingomyelin; SM, sphingomyelin; HexCer, hexosylceramide; GA1, asialo GM1.