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. 2021 Nov 1;24(12):103391. doi: 10.1016/j.isci.2021.103391

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Cananbis Research Trend

(A) Timeline of Cannabis records. Timeline and years from the earliest to the latest cannabis records in the literature databases of life science and biomedical journals are depicted with color coded radial bar for EuropePMC (green), Scopus (blue), NCBI PMC (gray), and Web of Science (lilac). The publication year of the first available Cannabis related document in each database is marked by a verticle line at top of corresponding bar. The number of years from the oldest available article to the most recent publication in 2021 are indicated at the base of each bar.

(B) Cannabis documents in the literature archives. The bar plot shows number of documents in the selected databases with Y axis divided into two sections to show the journals (upper section) and articles (lower section).

(C) Common citations in databases. EuropePMC, Scopus and NCBI PMC records were compared using DOI identifiers and number of shared and unique documents between three sets are shown as venn plot. The size of circle corresponds to number of articles with DOI in each database.

(D) Cannabis literature source in EuropePMC. Color coded pie chart depicts the source repositories of Cannabis articles in EuropePMC. The contribution (percentage of articles) from MEDLINE (MED), AGRICOLA (AGR), PubMed Central (PMC) and Chinese Biological Abstracts (CBA) are shown by orange, gray, turquoise, and cyan color.

(E) Cannabis Research trends. The overall pattern of Cannabis research from 1783 to 2021 is depicted by the trend line (log scaled) with each dot representing the number of articles (Y axis) per year (X axis). The research periods categorized as zero (1783–1840), I (1840–1937), II (1937–1996) and III (1996–2021) are separated by vertical dotted lines. The three major achievements (I) discovery of cannabinoids, ii) cannabinoid receptors and iii) endocannabinoids that pushed the interest in Cannabis are marked in pink color. The number of articles in 2021 are still growing and therefore depicted as hollow enlarged dot.

(F) Cannabis research subjects. Bubble plot depicts the most and least explored scientific subject areas with size corresponding to the number of articles (Y axis) and journals (Y axis) in each category. Major proportion of Cannabis research was related to medical and medicinal sciences followed by pharmacology and pharmaceuticals, neurosciences and psychology, biochemistry and biotechnology, genetics and genomic sciences, agriculture and plant biology, and bioinformatics.