Fig. 4.

Mechanism of TRPV2 activation in response to chemical ligand, heat and mechanical stimulation in the presence of oxidation. ChT oxidizes TRPV2 methionine residues (M528 and M607 in rat TRPV2). This oxidation is predicted to potentiate TRPV2 sensitivity to chemical and heat stimulation. ChT does not potentiate TRPV2 sensitivity to mechanical stimulation, which could instead affect cytoskeletal architecture (e.g., organization of actin filaments) to induce TRPV2 localization to the plasma membrane. This plasma membrane localization can promote TRPV2 activation that triggers further remodeling of the actin cytoskeleton and enhancement of cellular motility. Finally, TRPV2 activation potentiates mechanical sensitivity according to our previous finding.