Fig. 1 |. Age-adjusted and sex-adjusted incidence of fractures based on the number of hypoglycaemic episodes and baseline HbA_1c in a cohort of Japanese patients with T2DM.

Multiple episodes of hypoglycaemia are associated with a marked increase in fracture risk, and even a history of a single episode of hypoglycaemia results in an increase in fracture risk. In the absence of hypoglycaemia, fracture risk is increased significantly in patients with HbA_1c values ≥9%. *P < 0.01, **P < 0.001 versus the reference group (HbA_1c <7% without severe hypoglycaemia). Adapted with permission from Komorita et al. 2020²⁴.