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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Thromb Haemost. 2021 Sep 6;19(12):2997–3007. doi: 10.1111/jth.15510

Figure 2. Femoral vein electrolytic and FeCl3 models produce small thrombi with low RBC- and fibrin-content, whereas IVC stasis produces large, RBC-rich thrombi.

Figure 2.

Thrombosis was induced using femoral electrolytic injury (N=6), femoral FeCl3 injury (N=8), and IVC stasis (N=5). (A) Representative whole thrombi (top row) and enlarged images (middle row) stained by H&E, and fibrin staining (brown, bottom row). Black arrows indicate areas rich in RBCs. (B) RBC content of thrombi from each model; data on human PE (hPE) are reproduced from Figure 1G. (C) Fibrin staining intensity of thrombi from each model. RBC data were normally distributed and compared using one-way ANOVA. The fibrin intensity data were not normally distributed and were compared using Kruskal-Wallis testing. Dots represent individual mice; columns and error bars indicate mean and standard deviation for RBCs, and median and interquartile range for fibrin. ****P<0.0001; ns, non-significant