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. Author manuscript; available in PMC: 2022 Oct 6.
Published in final edited form as: ACS Chem Neurosci. 2021 Sep 13;12(19):3733–3744. doi: 10.1021/acschemneuro.1c00492

Figure 5.

Figure 5.

[11C]CS1P1 metabolism analysis and kinetic model fitting of [11C]CS1P1 uptake in the NHP brain. (A,B) Ex vivo [11C]CS1P1 metabolism analysis in rodent and non-human primate plasma and brain: (A) [11C]CS1P1 plasma metabolism analysis in NHP showed no major metabolites in NHP blood; (B) [11C]CS1P1 plasma metabolism analysis in rat showed a small amount of metabolite in rat blood at 5 min and no to very low amount in later time point, [11C]CS1P1 brain metabolism analysis in rat showed no metabolites in the homogenates of the rat brain. (C) Time-activity curves for NHP whole blood and plasma: whole-blood, whole-blood fit to three exponential model to define the blood curve, and the parent mcPIF is shown. (D–F) Kinetic model fitting of [11C]CS1P1 uptake in the NHP brain: (D) 2-tissue compartmental model fit to the total brain uptake; (E–F) 2-tissue compartment model regression against time-activity curves of select brain regions.