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. 2021 Nov 16;14:8217–8229. doi: 10.2147/IJGM.S335090

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© 2021 Zhou et al.

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Manhattan map of all SNP sites (A) and Manhattan map of significant SNP mutation sites, marks the SNP sites with high significance (P<1e-9) (B).

Note: X-axis was the position of the chromosome where the SNP was located. Y-axis was the -log₁₀(P) value corresponding to each SNP site. -log₁₀(P) reflects the degree of association between mutation site and disease occurrence. The greater the value of -log₁₀(P), the stronger the association. The blue horizontal line cutoff value was P=1e-5, and the red horizontal line cutoff value was P=1e-8.