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. 2021 Nov 16;299:246–255. doi: 10.1016/j.jad.2021.11.030

Table 2.

Boy's (n = 89) and girls’ (n = 86) trajectories of depression from before to after COVID-19 pandemic onset.

Model 1
Model 2 (+ loneliness)
Model 3 (+ social video game time)
Model 4 (+ social media use time)
Model 5 (+ social activity participation)
Timepoint Boys Girls Boys vs. girls pa Boys Girls Boys vs. girls pa Boys Girls Boys vs. girls pa Boys Girls Boys vs. girls pa Boys Girls Boys vs. girls pa
All Low lonelinessb Low social video game timeb Low social media use timeb Low social activity participationb
Mean CDI score (SE)
 Pre-COVID (T1) 3.91 (0.37) 4.35 (0.36) 2.97 (0.36) 3.18 (0.42) 3.41 (0.72) 4.21 (0.42) 3.93 (0.37) 3.96 (0.48) 4.32 (0.44) 4.70 (0.46)
 Acute (T2) 3.94 (0.36) 5.66 (0.36) ** 2.57 (0.35) 4.14 (0.41) * 4.15 (0.67) 5.30 (0.43) 3.91 (0.36) 5.02 (0.48) 4.42 (0.42) 5.86 (0.45)
 Persistent (T3) 4.95 (0.37) 6.07 (0.37) * 3.59 (0.37) 4.86 (0.43) 5.13 (0.69) 5.74 (0.45) 4.93 (0.37) 5.42 (0.49) 5.41 (0.44) 6.04 (0.47)
Change over time (SE)c
 Δ Acute – Pre-COVID 0.03 (0.29) 1.31 (0.27)** ** −0.39 (0.33) 0.96 (0.38) ** 0.74 (0.64) 1.09 (0.29)** ** −0.02 (0.31) 1.06 (0.39)* ** 0.10 (0.35) 1.16 (0.34)** **
 Δ Persistent – Acute 1.02 (0.33)* 0.41 (0.34) ** 1.02 (0.38) 0.72 (0.45) ** 0.97 (0.64) 0.44 (0.41) ** 1.02 (0.34) 0.40 (0.46) ** 0.99 (0.40) 0.18 (0.42) **

High lonelinessb High social video game timeb High social media use timeb High social activity participationb
Mean CDI score (SE)
 Pre-COVID (T1) 4.70 (0.41) 5.11 (0.32) 3.98 (0.40) 4.20 (0.88) 3.57 (0.49) 4.50 (0.37) 3.45 (0.45) 4.11 (0.42)
 Acute (T2) 5.47 (0.37) 6.53 (0.34) 3.91 (0.40) 6.91 (0.76) ** 3.61 (0.51) 5.84 (0.37) ** 3.38 (0.44) 5.52 (0.42) **
 Persistent (T3) 6.45 (0.39) 6.75 (0.36) 4.91 (0.41) 7.02 (0.78) 5.07 (0.52) 6.28 (0.39) 4.44 (0.45) 6.19 (0.43) *
Change over time (SE)c
 Δ Acute – Pre-COVID 0.77 (0.41) 1.42 (0.27)** ** −0.07 (0.31) 2.71 (0.84)** ** 0.04 (0.37) 1.34 (0.27)** ** −0.08 (0.37) 1.41 (0.34)** **
 Δ Persistent – Acute 0.99 (0.41) 0.22 (0.38) ** 1.00 (0.38) 0.12 (0.72) ** 1.46 (0.48) 0.44 (0.35) ** 1.07 (0.40) 0.67 (0.41) **

Differences by social connectednessd High vs. low loneliness High vs. low social video game time High vs. low social media use time High vs. low social activity participation
Mean CDI score (SE)
 Pre-COVID (T1) 1.73 (0.44)** 1.93 (0.40)** 0.57 (0.77) −0.01 (1.01) −0.36 (0.38) 0.54 (0.41) -0.86 (0.50) -0.59 (0.51)
 Acute (T2) 2.89 (0.39)** 2.39 (0.42)** −0.24 (0.75) 1.61 (0.90) −0.30 (0.38) 0.82 (0.41)* -1.04 (0.47) -0.34 (0.49)
 Persistent (T3) 2.86 (0.41)** 1.89 (0.44)** −0.22 (0.77) 1.29 (0.93) 0.14 (0.39) 0.86 (0.42)* -0.97 (0.49) −0.14 (0.51)
Change over time (SE)c
 Δ Acute – Pre-COVID 1.16 (0.04)** 0.46 (0.04)** −0.81 (0.05)** 1.62 (0.07)** 0.06 (0.04)* 0.28 (0.04)** −0.18 (0.04)** 0.26 (0.04)**
 Δ Persistent – Acute −0.03 (0.04) −0.50 (0.05)** 0.03 (0.06) -0.32 (0.06)** 0.44 (0.04)** 0.04 (0.04) 0.08 (0.04) 0.48 (0.04)**

Note. *p < .05, **p < .01.

Mean CDI score is estimated by the fitted model at the median timepoint of assessment for each period (median no. weeks from state shutdown: T1: −109, T2: 7, T3: 33). All models are adjusted for age. Models 2–5 additionally include domains of social connectedness: loneliness (model 2), social video game time (model 3), social media use time (model 4), and social activity participation (model 5); these were modeled using 3-way interactions between social exposure*sex*time.

a

Differences by sex were compared using two-tailed Welch's t-test.

b

Low and high loneliness, social video game time and social media use time were set at the 25th and 75th percentile values in the sample. Loneliness: low = 4.0 vs. high = 9.5 points; social video game time: low = 0 vs. high = 5.2 h; social media use time: low = 2–3, high = 4–6 h; social activity participation sum score: low = 4, high = 8 activities.

c

Mean change between timepoints were estimated using model-predicted CDI score at median weeks from shutdown, stratified by sex.

d

p-values are for test of differences between high vs. low social connectedness variables in mean CDI score and change in mean CDI score over time.