FIG. 4.
The FER-1 element and the proximal AP1/NF-E2 site contain a canonical electrophile response sequence. The 75-bp cis-acting element responsible for transcriptional activation of the mouse ferritin H gene by t-BHQ contains the FER-1 element and an AP1/NF-E2 site, whose DNA sequence is shown. The consensus EpRE sequence (47) conserved in this region is shaded. The two EpREs of the ferritin H gene and the EpRE of the ferritin L gene (47) were aligned with the consensus EpRE sequence, in which the core sequence (36) is underlined.