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. Author manuscript; available in PMC: 2021 Nov 21.
Published in final edited form as: Nat Med. 2021 Oct 18;27(11):1982–1989. doi: 10.1038/s41591-021-01522-3

Extended Data Fig. 6 |. Study 2 histological and molecular readouts.

Extended Data Fig. 6 |

a, Quantitation of lesion scores from cerebellar sections of NHPs injected with the indicated AAVs (Empty, miSCA7, Stuffer, IntmiS1). Each dot represents a single animal. b, Human ATXN1L levels normalized to endogenous GAPDH as assessed by RT-qPCR. c, Total read counts of human ATXN1L by RNA-seq. d, miS1 levels in AAV.IntmiS1 treated animals, normalized to endogenous U6 RNA and relative to empty capsid treated animals. e, Ionized calcium binding adapter molecule 1 (IBA1) mRNA levels. f, Glial fibrillary acidic protein (GFAP) mRNA levels. Data are represented as mean ± SEM (N = 3 animals per group). There was no significant difference as measured by two-way ANOVA followed by a Dunnett’s multiple comparisons post hoc.