TABLE 1.
Type of tumor | No. of tumors/no. of mice
|
|
---|---|---|
Ras | Ras-TEL | |
Total | 14/14 | 15/15 |
Invasiveb | 13/14 | ±3d/15 |
Metastaticc | 2/14 | 0/15 |
Single cell suspensions containing the listed constructs (polyclonal) were injected into a single site in the right flank of 7-week-old female athymic nude mice. Mice were then monitored for tumor formation.
Invasiveness was determined at the time of autopsy by inspection of the tumor and histologic analysis.
Metastatic tumors were found in the lymph nodes.
Tumors showing limited invasion.