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. 2021 Nov 20;7:361. doi: 10.1038/s41420-021-00605-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The blood glucose level in the mouse model. B Western blot results of FBW7 expression in islets from T1D mice (n = 10) and control mice (n = 10), *p < 0.05, vs. the normal group. C Representative images of IHC for FBW7 expression in islets from T1D mice and control mice with arrows pointing at cells positive for FBW7 (bar = 25 μm). Measurement data are presented. Data comparisons between two groups were analyzed by unpaired t-test. Statistical analysis in relation to time-based measurements within each group was realized using repeated-measures ANOVA.