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. 2021 Nov 20;7:361. doi: 10.1038/s41420-021-00605-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A The diabetes incidence of each group. B The islet size of each group. C FBW7 expression in mice islet of each group determined by Western blot analysis. D FBW7 expression in induced splenocytes and pancreatic beta cells of each group was determined by Western blot analysis. E The levels of IL-17A, IL-2, IFN-γ, and IL-4 in cell supernatant of each group were determined by ELISA. F The pancreatic beta-cell apoptosis of each group was determined by flow cytometry. G The insulin secretion of each group. *p < 0.05, vs. the normal group, ^#p < 0.05, vs. the OE-NC group. All experiments were conducted in triplicate. Data comparisons between two groups were analyzed by unpaired t-test. Comparisons among multiple groups were performed by one-way ANOVA. Statistical analysis in relation to time-based measurements within each group was realized using repeated-measures ANOVA.