Figure 1 –

Diagram of clinical β-cell replacement treatment alternatives, highlighting major advantages and disadvantages of each procedure.

* Data from observational retrospective single center non-randomized or registries studies.

$ Data from randomized clinical trials

¥ Compared to Kidney Transplant Alone

# Compared to islet transplantation

& Compared to Pancreas Transplantation

BMI – Body Mass Index; CVD – Cardiovascular disease; IAH – Impaired hypoglycemia awareness; KTA – Kidney Transplant Alone ; MACE – Major Adverse Cardiovascular Events; QoL – Quality of Life