Table 5.
SNPs with nominal p-values for association with diabetes up to 5 years after a pregnancy complicated by GDM
| SNP | Gene/nearest gene | Location | CHR | RA/OA | OR (CI) | p value | p value (FDR_BH) |
|---|---|---|---|---|---|---|---|
| rs4607103 | ADAMTS9-AS2 | Intron | 3 | C/T |
0.47 (0.30–0.73) |
0.00055 | 0.039 |
| rs4607517 | GCK | Intergenic | 7 | A/G |
1.765 (1.09–2.85) |
0.019 | 0.4902 |
| rs1552224 | CENTD2 | Intergenic | 11 | A/C |
2.22 (1.09–4.61) |
0.024 | 0.4902 |
| rs11634397 | ZFAND6 | Intergenic | 15 | G/A |
1.58 (1.03–2.42) |
0.037 | 0.4902 |
| rs7578597 | THADA | Coding—missense | 2 | T/C |
3.29 (1.004–10.75) |
0.037 | 0.4902 |
| rs4457053 | ZBED3 | Intron of ZBED3-AS1 | 5 | G/A |
1.56 (1.02–2.38) |
0.041 | 0.4902 |
SNP = single nucleotide polymorphism, CHR = chromosome, SNP = single nucleotide polymorphisms, RA/OA = risk allele/other allele, OR = estimated odds ratio (for risk), P value = nominal p-value for this test, FDR_BH = Benjamini & Hochberg (1995) step-up FDR control