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. 2021 Nov 20;21:1254. doi: 10.1186/s12885-021-08998-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The nociceptor marker calcitonin gene-related peptide (CGRP) was correlated with both PNI and LNM in OSCC patients. A Kaplan–Meier survival analysis of cancer patients stratified by different neuropeptide mRNA levels according to the TCGA database. B Protein expression of CGRP in tumor tissues and adjacent normal tissues in PNI(−) and PNI(+) OSCC tissues. C Representative IHC images of OSCC tissues with different CGRP staining intensity. D Representative IHC images of PNI tissue from OSCC patients stained for CGRP and the nerve marker PGP9.5. E Quantification of CGRP scores in PNI(−) and PNI(+) OSCC tissues. F Representative immunohistochemistry images of a metastatic lymph node stained for CGRP. G CGRP staining levels in LNM(−) and LNM(+) OSCC tissues. BRCA, Breast invasive carcinoma; COAD, Colon adenocarcinoma; ESCA, Esophageal carcinoma; GBM, Glioblastoma multiforme; HNSCC, Head and Neck squamous cell carcinoma; LGG, Brain Lower Grade Glioma; LUSC, Lung squamouscell carcinoma