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The decrease of iCAFs accompanied BLCA pathogenesis. A The expression of marker genes for iCAFs was significantly reduced in BLCA compared with normal tissues. B GO and KEGG enrichment analysis indicated decreased extracellular matrix in BLCA, further suggesting reduced fibroblasts in BLCA pathogenesis. C ROC curves showed high diagnostic values of various iCAFs marker genes. D Immunohistochemistry assays confirmed the reduction of iCAFs markers in BLCA, including CXCL12, PDGFRA and VIM
