TABLE 1.
Urine and serum solutes of euhydrated Aldor1+/+ and Aldor1−/− micea
| Sample and substance | Aldor1+/+ | Aldor1−/− |
|---|---|---|
| Urine | Concn | |
| Osm (mmol/kg) | 3,173 ± 194 | 1,128 ± 54* |
| Na (mmol/liter) | 138.7 ± 8.3 | 59.5 ± 3.2* |
| K (mmol/liter) | 376.6 ± 22.0 | 147.2 ± 4.6* |
| Ca (mmol/liter) | 3.5 ± 0.3 | 1.4 ± 0.1* |
| Cl (mmol/liter) | 182.6 ± 12.0 | 70.43 ± 2.0* |
| Creatinine (μmol/liter) | 5,493 ± 306 | 2,257 ± 88* |
| Urea (mmol/liter) | 1,367 ± 68 | 569.7 ± 21* |
| AVP (ng/ml) | 0.80 ± 0.17 | 0.56 ± 0.11** |
| Serum | ||
| Osm (mmol/kg) | 316.9 ± 1.0 | 317.3 ± 1.4 |
| Na (mmol/liter) | 151.5 ± 0.5 | 153.6 ± 0.6 |
| K (mmol/liter) | 4.4 ± 0.08 | 4.4 ± 0.12 |
| Ca (mmol/liter) | 2.2 ± 0.02 | 2.3 ± 0.02 |
| Cl (mmol/liter) | 114.1 ± 0.5 | 115.5 ± 0.8 |
| Urea (mmol/liter) | 11.0 ± 0.6 | 10.6 ± 0.5 |
| Creatinine (μmol/liter) | 40.6 ± 1.2 | 44.3 ± 1.6 |
| Albumin (g/liter) | 25.6 ± 0.5 | 25.4 ± 1.1 |
| Urine | 24-h excretion | |
| Na (mmol) | 0.27 ± 0.02 | 0.31 ± 0.02 |
| K (mmol) | 0.68 ± 0.05 | 0.76 ± 0.02 |
| Ca (mmol) | 0.0059 ± 0.0005 | 0.0067 ± 0.0004 |
| Cl (mmol) | 0.32 ± 0.03 | 0.36 ± 0.02 |
| Creatinine (μmol) | 10.0 ± 0.8 | 11.9 ± 0.6 |
| Urea (mmol) | 2.5 ± 0.18 | 3.0 ± 0.11 |
| AVP (ng) | 1.6 ± 0.3 | 3.6 ± 0.7*** |
a
Values are means ± standard errors of the means (n = 10). *, P < 0.0001; **, P = 0.2551; ***, P = 0.0215 compared with Aldor1+/+ mice. Osm, osmolality.